Layer count factors as a strong driver of cost increases for bonded plastic manifolds. More layers means higher cost, but nominally so as each individual layer typically comes in at around the same cost. A single layer, drilled solution has a significantly lower cost than a multilayer bonded solution as they consist of only one layer versus two or more that require more machining. As such, two-layer bonded manifolds contain three parts in one here with 2 layers bonded and the final finishing "layer".
When thinking about price per manifold, a good rule of thumb is a medium size and complexity two layer manifold costs about $200 in quantity (100 pcs). Three layers is $300, and four layers totals around $400 each.
How do we eliminate the bonding while still getting the nice benefit of all top mount connections? Designers can accomplish this with angled holes. If your application allows, simplify the design by incorporating angled holes. Traditionally, designers have avoided this approach because of cost. Extra angled fixturing increased that price quickly.
But times have changed. With the arrival of low-cost 5thaxis trunnions, angle holes are the same cost as straight drilled holes. Angle choice is flexible, and the trunnions can reach any position with ease.